About Polyadenylate-binding protein 1-like
Polyadenylate-binding protein 1-like (PABPC1L) is a protein
from Homo sapiens identified by UniProt accession
Q4VXU2, 619 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Polyadenylate-binding protein 1-like |
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| UniProt accession | Q4VXU2 |
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| Gene | PABPC1L |
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| Organism | Homo sapiens |
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| Length | 619 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- female infertility due to zona pellucida defect · score 0.42
- blood protein measurement · score 0.27
- inherited oocyte maturation defect · score 0.26
- chronotype measurement · score 0.23
- serum albumin measurement · score 0.17
- sleep duration · score 0.17
- age at menarche · score 0.16
- lean body mass · score 0.10
- body mass index · score 0.09
- Female infertility due to fertilization defect · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4VXU2-F1 | alphafold | PREDICTED | 75.69 | — |
Amino-acid sequence (619 residues)
MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR SLGYAYINFQ QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN IFIKNLEDSI DNKALYDTFS TFGNILSCKV ACDEHGSRGF GFVHFETHEA AQQAINTMNG MLLNDRKVFV GHFKSRRERE AELGARALEF TNIYVKNLPV DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK HEEAQKAVVH MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV TEMNGRIVGT KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF QQPSSYFLPA MPQPPAQAAY YGCGPVTPTQ PAPRWTSQPP RPSSAYPPGA SMVRPPVVPR RPPAHISSVR QASTQVPRTV PHTQRVANIG TQTTGPSGVG CCTPGRPLLP CKCSSAAHST YRVQEPAVHI PGQEPLTASM LAAAPLHEQK QMIGERLYPL IHDVHTQLAG KITGMLLEID NSELLLMLES PESLHAKIDE AVAVLQAHQA MEQPKAYMH
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