About Tigger transposable element-derived protein 2
Tigger transposable element-derived protein 2 (TIGD2) is a protein
from Homo sapiens identified by UniProt accession
Q4W5G0, 525 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Tigger transposable element-derived protein 2 |
|---|
| UniProt accession | Q4W5G0 |
|---|
| Gene | TIGD2 |
|---|
| Organism | Homo sapiens |
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| Length | 525 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.27
- mean platelet volume · score 0.22
- insulin like growth factor measurement · score 0.18
- urate measurement · score 0.16
- appendicular lean mass · score 0.10
- brain measurement · score 0.10
- cortical surface area measurement · score 0.10
- vital capacity · score 0.09
- FEV/FVC ratio · score 0.08
- body height · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4W5G0-F1 | alphafold | PREDICTED | 74.29 | — |
Amino-acid sequence (525 residues)
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRKKQKIQ NNKNH
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