Renal cancer differentiation gene 1 protein (C4orf46)

About Renal cancer differentiation gene 1 protein

Renal cancer differentiation gene 1 protein (C4orf46) is a protein from Homo sapiens identified by UniProt accession Q504U0, 113 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Renal cancer differentiation gene 1 protein
UniProt accession	Q504U0
Gene	C4orf46
Organism	Homo sapiens
Length	113 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

multiple acyl-CoA dehydrogenase deficiency · score 0.12
Glutaric aciduria · score 0.12
pulse pressure measurement · score 0.02
blood protein measurement · score 0.02
renal cell carcinoma · score 0.02
medulloblastoma · score 0.02
colorectal cancer · score 0.02
atypical teratoid rhabdoid tumor · score 0.01
nonpapillary renal cell carcinoma · score 0.01
primitive neuroectodermal tumor · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q504U0-F1	alphafold	PREDICTED	79.13	—

Amino-acid sequence (113 residues)

MADPEELQVS SPPPPPPSSP SSSDASAASS PGGPVSLGWP VPSRSSGPTV DQLEEVELQI GDAAFSLTKL LEATSAVSAQ VEELAFKCTE NARFLKTWRD LLKEGYDSLK PDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards