About Extracellular tyrosine-protein kinase PKDCC
Extracellular tyrosine-protein kinase PKDCC (PKDCC) is a protein
from Homo sapiens identified by UniProt accession
Q504Y2, 493 residues long.
MolForge cross-references it against 0 known binders and
353 disease associations.
Target properties
| Protein name | Extracellular tyrosine-protein kinase PKDCC |
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| UniProt accession | Q504Y2 |
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| Gene | PKDCC |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (353)
Diseases linked to this target (Open Targets).
- rhizomelic limb shortening with dysmorphic features · score 0.65
- heel bone mineral density · score 0.46
- hemoglobin measurement · score 0.44
- bone quantitative ultrasound measurement · score 0.43
- bone density · score 0.43
- cortical surface area measurement · score 0.42
- hematocrit · score 0.42
- cortical thickness · score 0.40
- blood protein measurement · score 0.40
- brain measurement · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q504Y2-F1 | alphafold | PREDICTED | 81.78 | — |
Amino-acid sequence (493 residues)
MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPE PSPAPGPGRR GGRGELARQI RARYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLPRP RPPWARPLSD GAPGWPPAPG PGSPGPGPRL GCAALRNVSG AQYMGSGYTK AVYRVRLPGG AAVALKAVDF SGHDLGSCVR EFGVRRGCYR LAAHKLLKEM VLLERLRHPN VLQLYGYCYQ DSEDIPDTLT TITELGAPVE MIQLLQTSWE DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVDGE LKVTDLDDAR VEETPCAGST DCILEFPARN FTLPCSAQGW CEGMNEKRNL YNAYRFFFTY LLPHSAPPSL RPLLDSIVNA TGELAWGVDE TLAQLEKVLH LYRSGQYLQN STASSSTEYQ CIPDSTIPQE DYRCWPSYHH GSCLLSVFNL AEAVDVCESH AQCRAFVVTN QTTWTGRQLV FFKTGWSQVV PDPNKTTYVK ASG
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