tRNA-splicing ligase complex subunit FAM98B (FAM98B)

About tRNA-splicing ligase complex subunit FAM98B

tRNA-splicing ligase complex subunit FAM98B (FAM98B) is a protein from Homo sapiens identified by UniProt accession Q52LJ0, 433 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	tRNA-splicing ligase complex subunit FAM98B
UniProt accession	Q52LJ0
Gene	FAM98B
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.25
mathematical ability · score 0.13
bipolar disorder · score 0.13
attention deficit hyperactivity disorder · score 0.12
platelet count · score 0.12
glomerular filtration rate · score 0.11
platelet crit · score 0.10
unipolar depression · score 0.10
Tourette syndrome · score 0.10
autism spectrum disorder · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q52LJ0-F1	alphafold	PREDICTED	72.59	—

Amino-acid sequence (433 residues)

MRGPEPGPQP TMEGDVLDTL EALGYKGPLL EEQALTKAAE GGLSSPEFSE LCIWLGSQIK SLCNLEESIT SAGRDDLESF QLEISGFLKE MACPYSVLIS GDIKDRLKKK EDCLKLLLFL STELQASQIL QNKKHKNSQL DKNSEVYQEV QAMFDTLGIP KSTTSDIPHM LNQVESKVKD ILSKVQKNHV GKPLLKMDLN SEQAEQLERI NDALSCEYEC RRRMLMKRLD VTVQSFGWSD RAKVKTDDIA RIYQPKRYAL SPKTTITMAH LLAAREDLSK IIRTSSGTSR EKTACAINKV LMGRVPDRGG RPNEIEPPPP EMPPWQKRQE GGGGRGGWGG GGGGGGRGGG GGGGGRGGWG GGGGGWGGGG GGGGGWGGGG GGGRGGFQGR GDYGGRGGYG GRGGYGGRGY GDPYGGGGGG GGGGGGGGGY RRY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards