About Enhancer of polycomb homolog 2
Enhancer of polycomb homolog 2 (EPC2) is a protein
from Homo sapiens identified by UniProt accession
Q52LR7, 807 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Enhancer of polycomb homolog 2 |
|---|
| UniProt accession | Q52LR7 |
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| Gene | EPC2 |
|---|
| Organism | Homo sapiens |
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| Length | 807 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- type 2 diabetes mellitus · score 0.34
- schizophrenia · score 0.31
- chronotype measurement · score 0.28
- heel bone mineral density · score 0.24
- metabolite measurement · score 0.23
- mean corpuscular volume · score 0.23
- body height · score 0.15
- FEV change measurement · score 0.09
- acute myeloid leukemia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q52LR7-F1 | alphafold | PREDICTED | 57.04 | — |
Amino-acid sequence (807 residues)
MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE SEHHLQRAIS AQQVFREKKE SMVIPVPEAE SNVNYYNRLY KGEFKQPKQF IHIQPFNLDN EQPDYDMDSE DETLLNRLNR KMEIKPLQFE IMIDRLEKAS SNQLVTLQEA KLLLNEDDYL IKAVYDYWVR KRKNCRGPSL IPQIKQEKRD GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE FSRAITILEM IKRREKTKRE LLHLTLEVVE KRYHLGDYGG EILNEVKISR SEKELYATPA TLHNGNHHKV QECKTKHPHH LSLKEEASDV VRQKKKYPKK PKAEALITSQ QPTPETLPVI NKSDIKQYDF HSSDEDEFPQ VLSPVSEPEE ENDPDGPCAF RRRAGCQYYA PRLDQANHSC ENSELADLDK LRYRHCLTTL TVPRRCIGFA RRRIGRGGRV IMDRISTEHD PVLKQIDPEM LNSFSSSSQT IDFSSNFSRT NASSKHCENR LSLSEILSNI RSCRLQCFQP RLLNLQDSDS EECTSRKPGQ TVNNKRVSAA SVALLNTSKN GISVTGGITE EQFQTHQQQL VQMQRQQLAQ LQQKQQSQHS SQQTHPKAQG SSTSDCMSKT LDSASAHFAA SAVVSAPVPS RSEVAKEQNT GHNNINGVVQ PSGTSKTLYS TNMALSSSPG ISAVQLVRTV GHTTTNHLIP ALCTSSPQTL PMNNSCLTNA VHLNNVSVVS PVNVHINTRT SAPSPTALKL ATVAASMDRV PKVTPSSAIS SIARENHEPE RLGLNGIAET TVAMEVT
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