Serine/threonine-protein kinase SBK1 (SBK1)

About Serine/threonine-protein kinase SBK1

Serine/threonine-protein kinase SBK1 (SBK1) is a protein from Homo sapiens identified by UniProt accession Q52WX2, 424 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase SBK1
UniProt accession	Q52WX2
Gene	SBK1
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (58)

Diseases linked to this target (Open Targets).

body mass index · score 0.27
acute myeloid leukemia · score 0.27
hip circumference · score 0.21
cystatin C measurement · score 0.20
physical activity measurement · score 0.15
tonsillectomy risk measurement · score 0.14
waist circumference · score 0.11
intelligence · score 0.11
smoking behavior · score 0.11
alcohol consumption measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q52WX2-F1	alphafold	PREDICTED	76.13	—

Amino-acid sequence (424 residues)

MSVGCPEPEP PRSLTCCGPG TAPGPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG KGTYGKVDLV VYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET EDCYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHGRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGLAV DTGVDVWAFG VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRPPAA GPLRLEAPGP LKRTVLTESG SGSRPAPPAV GSVPLPVPVP VPVPVPVPVP EPGLAPQGPP GRTDGRADKS KGQVVLATAI EICV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards