About Programmed cell death protein 4
Programmed cell death protein 4 (PDCD4) is a protein
from Homo sapiens identified by UniProt accession
Q53EL6, 469 residues long.
MolForge cross-references it against 0 known binders and
344 disease associations.
Target properties
| Protein name | Programmed cell death protein 4 |
|---|
| UniProt accession | Q53EL6 |
|---|
| Gene | PDCD4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 469 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (344)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.27
- lymphocyte percentage of leukocytes · score 0.27
- PHF-tau measurement · score 0.18
- lymphocyte count · score 0.18
- neutrophil percentage of leukocytes · score 0.17
- diet measurement · score 0.16
- electrocardiography · score 0.16
- body fat percentage · score 0.11
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53EL6-F1 | alphafold | PREDICTED | 76.56 | — |
Amino-acid sequence (469 residues)
MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY
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