About Tigger transposable element-derived protein 5
Tigger transposable element-derived protein 5 (TIGD5) is a protein
from Homo sapiens identified by UniProt accession
Q53EQ6, 642 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Tigger transposable element-derived protein 5 |
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| UniProt accession | Q53EQ6 |
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| Gene | TIGD5 |
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| Organism | Homo sapiens |
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| Length | 642 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- Red cell distribution width · score 0.17
- serum alanine aminotransferase measurement · score 0.10
- protein measurement · score 0.08
- serum metabolite measurement · score 0.07
- schizophrenia · score 0.04
- monocyte percentage of leukocytes · score 0.04
- HbA1c measurement · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53EQ6-F1 | alphafold | PREDICTED | 67.63 | — |
Amino-acid sequence (642 residues)
MYPAGPPAGP VPRRGRRPLP GPPAPAPAPV PAARPPPPAP GPRPRVAVKM AFRKAYSIKD KLQAIERVKG GERQASVCRD FGVPGGTLRG WLKDEPKLRW FLEQLGGEVG TQRKKMRLAN EEEIDRAVYA WFLALRQHGV PLSGPLIQAQ AEAFARQIYG PECTFKASHG WFWRWQKRHG ISSQRFYGEA GPPAPSPAPG PPVKEEPALP SGAGPLPDRA PAPPPPAEGG YGDEQIYSAS VTGLYWKLLP EQAAPPGAGD PGAGGCGRRW RGDRVTVLLA ANLTGSHKLK PLVIGRLPDP PSLRHHNQDK FPASYRYSPD AWLSRPLLRG WFFEEFVPGV KRYLRRSCLQ QKAVLLVAHP PCPSPAASMP ALDSEDAPVR CRPEPLGPPE ELQTPDGAVR VLFLSKGSSR AHIPAPLEQG VVAAFKQLYK RELLRLAVSC ASGSPLDFMR SFMLKDMLYL AGLSWDLVQA GSIERCWLLG LRAAFEPRPG EDSAGQPAQA EEAAEHSRVL SDLTHLAALA YKCLAPEEVA EWLHLDDDGG PPEGCREEVG PALPPAAPPA PASLPSAMGG GEDEEEATDY GGTSVPTAGE AVRGLETALR WLENQDPREV GPLRLVQLRS LISMARRLGG IGHTPAGPYD GV
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