About CREB-regulated transcription coactivator 2
CREB-regulated transcription coactivator 2 (CRTC2) is a protein
from Homo sapiens identified by UniProt accession
Q53ET0, 693 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | CREB-regulated transcription coactivator 2 |
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| UniProt accession | Q53ET0 |
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| Gene | CRTC2 |
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| Organism | Homo sapiens |
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| Length | 693 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (139)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- mathematical ability · score 0.08
- head and neck squamous cell carcinoma · score 0.07
- cognitive function measurement · score 0.07
- hepatocellular carcinoma · score 0.07
- Autosomal dominant polycystic kidney disease · score 0.07
- neuroimaging measurement · score 0.07
- prostate carcinoma · score 0.07
- self reported educational attainment · score 0.07
- intelligence · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53ET0-F1 | alphafold | PREDICTED | 48.60 | — |
Amino-acid sequence (693 residues)
MATSGANGPG SATASASNPR KFSEKIALQK QRQAEETAAF EEVMMDIGST RLQAQKLRLA YTRSSHYGGS LPNVNQIGSG LAEFQSPLHS PLDSSRSTRH HGLVERVQRD PRRMVSPLRR YTRHIDSSPY SPAYLSPPPE SSWRRTMAWG NFPAEKGQLF RLPSALNRTS SDSALHTSVM NPSPQDTYPG PTPPSILPSR RGGILDGEMD PKVPAIEENL LDDKHLLKPW DAKKLSSSSS RPRSCEVPGI NIFPSPDQPA NVPVLPPAMN TGGSLPDLTN LHFPPPLPTP LDPEETAYPS LSGGNSTSNL THTMTHLGIS RGMGLGPGYD APGLHSPLSH PSLQSSLSNP NLQASLSSPQ PQLQGSHSHP SLPASSLARH VLPTTSLGHP SLSAPALSSS SSSSSTSSPV LGAPSYPAST PGASPHHRRV PLSPLSLLAG PADARRSQQQ LPKQFSPTMS PTLSSITQGV PLDTSKLSTD QRLPPYPYSS PSLVLPTQPH TPKSLQQPGL PSQSCSVQSS GGQPPGRQSH YGTPYPPGPS GHGQQSYHRP MSDFNLGNLE QFSMESPSAS LVLDPPGFSE GPGFLGGEGP MGGPQDPHTF NHQNLTHCSR HGSGPNIILT GDSSPGFSKE IAAALAGVPG FEVSAAGLEL GLGLEDELRM EPLGLEGLNM LSDPCALLPD PAVEESFRSD RLQ
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