Glycerol-3-phosphate acyltransferase 3 (GPAT3)

About Glycerol-3-phosphate acyltransferase 3

Glycerol-3-phosphate acyltransferase 3 (GPAT3) is a protein from Homo sapiens identified by UniProt accession Q53EU6, 434 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	Glycerol-3-phosphate acyltransferase 3
UniProt accession	Q53EU6
Gene	GPAT3
Organism	Homo sapiens
Length	434 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (99)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.45
reticulocyte count · score 0.12
neoplasm · score 0.10
cyst · score 0.10
upper aerodigestive tract neoplasm · score 0.06
non-alcoholic fatty liver disease · score 0.06
infect · score 0.04
infection · score 0.04
clear cell renal carcinoma · score 0.04
Generalized congenital lipodystrophy with myopathy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53EU6-F1	alphafold	PREDICTED	85.31	—

Amino-acid sequence (434 residues)

MEGAELAGKI LSTWLTLVLG FILLPSVFGV SLGISEIYMK ILVKTLEWAT IRIEKGTPKE SILKNSASVG IIQRDESPME KGLSGLRGRD FELSDVFYFS KKGLEAIVED EVTQRFSSEE LVSWNLLTRT NVNFQYISLR LTMVWVLGVI VRYCVLLPLR VTLAFIGISL LVIGTTLVGQ LPDSSLKNWL SELVHLTCCR ICVRALSGTI HYHNKQYRPQ KGGICVANHT SPIDVLILTT DGCYAMVGQV HGGLMGIIQR AMVKACPHVW FERSEMKDRH LVTKRLKEHI ADKKKLPILI FPEGTCINNT SVMMFKKGSF EIGGTIHPVA IKYNPQFGDA FWNSSKYNMV SYLLRMMTSW AIVCDVWYMP PMTREEGEDA VQFANRVKSA IAIQGGLTEL PWDGGLKRAK VKDIFKEEQQ KNYSKMIVGN GSLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards