Leucine-rich repeat-containing protein 23 (LRRC23)

About Leucine-rich repeat-containing protein 23

Leucine-rich repeat-containing protein 23 (LRRC23) is a protein from Homo sapiens identified by UniProt accession Q53EV4, 343 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 23
UniProt accession	Q53EV4
Gene	LRRC23
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.20
nitric oxide exhalation measurement · score 0.15
self reported educational attainment · score 0.14
systolic blood pressure · score 0.14
genetic disorder · score 0.12
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.10
colorectal cancer · score 0.09
spermatogenic failure 49 · score 0.09
spermatogenic failure 43 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53EV4-F1	alphafold	PREDICTED	88.22	—

Amino-acid sequence (343 residues)

MSDEDDLEDS EPDQDDSEKE EDEKETEEGE DYRKEGEEFP EEWLPTPLTE DMMKEGLSLL CKTGNGLAHA YVKLEVKERD LTDIYLLRSY IHLRYVDISE NHLTDLSPLN YLTHLLWLKA DGNRLRSAQM NELPYLQIAS FAYNQITDTE GISHPRLETL NLKGNSIHMV TGLDPEKLIS LHTVELRGNQ LESTLGINLP KLKNLYLAQN MLKKVEGLED LSNLTTLHLR DNQIDTLSGF SREMKSLQYL NLRGNMVANL GELAKLRDLP KLRALVLLDN PCTDETSYRQ EALVQMPYLE RLDKEFYEEE ERAEADVIRQ RLKEEKEQEP EPQRDLEPEQ SLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards