About Nuclear cap-binding protein subunit 3
Nuclear cap-binding protein subunit 3 (NCBP3) is a protein
from Homo sapiens identified by UniProt accession
Q53F19, 620 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Nuclear cap-binding protein subunit 3 |
|---|
| UniProt accession | Q53F19 |
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| Gene | NCBP3 |
|---|
| Organism | Homo sapiens |
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| Length | 620 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (16)
Diseases linked to this target (Open Targets).
- monocyte percentage of leukocytes · score 0.21
- mean corpuscular hemoglobin · score 0.12
- mean corpuscular hemoglobin concentration · score 0.11
- Herpes simplex virus 2 seropositivity · score 0.10
- viral disease · score 0.02
- infection · score 0.02
- infect · score 0.02
- lung adenocarcinoma · score 0.01
- cancer · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53F19-F1 | alphafold | PREDICTED | 62.81 | — |
Amino-acid sequence (620 residues)
MAAVRGLRVS VKAEAPAGPA LGLPSPEAES GVDRGEPEPM EVEEGELEIV PVRRSLKELI PDTSRRYENK AGSFITGIDV TSKEAIEKKE QRAKRFHFRS EVNLAQRNVA LDRDMMKKAI PKVRLETIYI CGVDEMSTQD VFSYFKEYPP AHIEWLDDTS CNVVWLDEMT ATRALINMSS LPAQDKIRSR DASEDKSAEK RKKDKQEDSS DDDEAEEGEV EDENSSDVEL DTLSQVEEES LLRNDLRPAN KLAKGNRLFM RFATKDDKKE LGAARRSQYY MKYGNPNYGG MKGILSNSWK RRYHSRRIQR DVIKKRALIG DDVGLTSYKH RHSGLVNVPE EPIEEEEEEE EEEEEEEEED QDMDADDRVV VEYHEELPAL KQPRERSASR RSSASSSDSD EMDYDLELKM ISTPSPKKSM KMTMYADEVE SQLKNIRNSM RADSVSSSNI KNRIGNKLPP EKFADVRHLL DEKRQHSRPR PPVSSTKSDI RQRLGKRPHS PEKAFSSNPV VRREPSSDVH SRLGVPRQDS KGLYADTREK KSGNLWTRLG SAPKTKEKNT KKVDHRAPGA EEDDSELQRA WGALIKEKEQ SRQKKSRLDN LPSLQIEVSR ESSSGSEAES
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