Metallophosphoesterase 1 (MPPE1)

About Metallophosphoesterase 1

Metallophosphoesterase 1 (MPPE1) is a protein from Homo sapiens identified by UniProt accession Q53F39, 396 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Metallophosphoesterase 1
UniProt accession	Q53F39
Gene	MPPE1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

arterial stiffness measurement · score 0.32
neoplasm · score 0.12
alcohol drinking · score 0.09
cancer · score 0.08
reticulocyte count · score 0.06
breast cancer · score 0.06
melanoma · score 0.05
chronic obstructive pulmonary disease · score 0.04
infection · score 0.04
infect · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53F39-F1	alphafold	PREDICTED	89.71	—

Amino-acid sequence (396 residues)

MAMIELGFGR QNFHPLKRKS SLLLKLIAVV FAVLLFCEFL IYYLAIFQCN WPEVKTTASD GEQTTREPVL KAMFLADTHL LGEFLGHWLD KLRREWQMER AFQTALWLLQ PEVVFILGDI FDEGKWSTPE AWADDVERFQ KMFRHPSHVQ LKVVAGNHDI GFHYEMNTYK VERFEKVFSS ERLFSWKGIN FVMVNSVALN GDGCGICSET EAELIEVSHR LNCSREARGS SRCGPGPLLP TSAPVLLQHY PLYRRSDANC SGEDAAPAEE RDIPFKENYD VLSREASQKL LWWLQPRLVL SGHTHSACEV HHGGRVPELS VPSFSWRNRN NPSFIMGSIT PTDYTLSKCY LPREDVVLII YCGVVGFLVV LTLTHFGLLA SPFLSGLNLL GKRKTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards