About Acyl-coenzyme A synthetase ACSM3, mitochondrial
Acyl-coenzyme A synthetase ACSM3, mitochondrial (ACSM3) is a protein
from Homo sapiens identified by UniProt accession
Q53FZ2, 586 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Acyl-coenzyme A synthetase ACSM3, mitochondrial |
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| UniProt accession | Q53FZ2 |
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| Gene | ACSM3 |
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| Organism | Homo sapiens |
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| Length | 586 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.52
- neurodevelopmental disorder with speech delay and variable ocular anomalies · score 0.50
- genetic disorder · score 0.34
- glioblastoma multiforme · score 0.28
- urate measurement · score 0.27
- adolescent idiopathic scoliosis · score 0.17
- urinary metabolite measurement · score 0.16
- eosinophil count · score 0.16
- body height · score 0.15
- mean corpuscular volume · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53FZ2-F1 | alphafold | PREDICTED | 90.09 | — |
Amino-acid sequence (586 residues)
MLARVTRKML RHAKCFQRLA IFGSVRALHK DNRTATPQNF SNYESMKQDF KLGIPEYFNF AKDVLDQWTD KEKAGKKPSN PAFWWINRNG EEMRWSFEEL GSLSRKFANI LSEACSLQRG DRVILILPRV PEWWLANVAC LRTGTVLIPG TTQLTQKDIL YRLQSSKANC IITNDVLAPA VDAVASKCEN LHSKLIVSEN SREGWGNLKE LMKHASDSHT CVKTKHNEIM AIFFTSGTSG YPKMTAHTHS SFGLGLSVNG RFWLDLTPSD VMWNTSDTGW AKSAWSSVFS PWIQGACVFT HHLPRFEPTS ILQTLSKYPI TVFCSAPTVY RMLVQNDITS YKFKSLKHCV SAGEPITPDV TEKWRNKTGL DIYEGYGQTE TVLICGNFKG MKIKPGSMGK PSPAFDVKIV DVNGNVLPPG QEGDIGIQVL PNRPFGLFTH YVDNPSKTAS TLRGNFYITG DRGYMDKDGY FWFVARADDV ILSSGYRIGP FEVENALNEH PSVAESAVVS SPDPIRGEVV KAFVVLNPDY KSHDQEQLIK EIQEHVKKTT APYKYPRKVE FIQELPKTIS GKTKRNELRK KEWKTI
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