Kelch-like protein 12 (KLHL12)

About Kelch-like protein 12

Kelch-like protein 12 (KLHL12) is a protein from Homo sapiens identified by UniProt accession Q53G59, 568 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Kelch-like protein 12
UniProt accession	Q53G59
Gene	KLHL12
Organism	Homo sapiens
Length	568 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
mean platelet volume · score 0.21
primary biliary cirrhosis · score 0.09
macula measurement · score 0.02
hepatocellular carcinoma · score 0.01
attention deficit hyperactivity disorder · score 0.01
juvenile dermatomyositis · score 0.01
Sjogren syndrome · score 0.01
acute quadriplegic myopathy · score 0.00
hemoglobin measurement · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53G59-F1	alphafold	PREDICTED	93.32	—

Amino-acid sequence (568 residues)

MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ ACCEFLESQL DPSNCLGIRD FAETHNCVDL MQAAEVFSQK HFPEVVQHEE FILLSQGEVE KLIKCDEIQV DSEEPVFEAV INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP FIRCSLQCRD LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD YTADEDGVWY SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD PNIDQWSMLG DMQTAREGAG LVVASGVIYC LGGYDGLNIL NSVEKYDPHT GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG FDGTAHLSSV EAYNIRTDSW TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY DPIIDSWEVV TSMGTQRCDA GVCVLREK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards