About Pleckstrin homology-like domain family A member 2
Pleckstrin homology-like domain family A member 2 (PHLDA2) is a protein
from Homo sapiens identified by UniProt accession
Q53GA4, 152 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | Pleckstrin homology-like domain family A member 2 |
|---|
| UniProt accession | Q53GA4 |
|---|
| Gene | PHLDA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 152 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.19
- creatinine measurement · score 0.16
- bilirubin measurement · score 0.14
- low density lipoprotein cholesterol measurement · score 0.14
- body height · score 0.11
- calcium measurement · score 0.10
- high density lipoprotein cholesterol measurement · score 0.10
- platelet count · score 0.10
- hepatocellular carcinoma · score 0.10
- apolipoprotein A 1 measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GA4-F1 | alphafold | PREDICTED | 84.78 | — |
Amino-acid sequence (152 residues)
MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP
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