About Choline transporter-like protein 4
Choline transporter-like protein 4 (SLC44A4) is a protein
from Homo sapiens identified by UniProt accession
Q53GD3, 710 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | Choline transporter-like protein 4 |
|---|
| UniProt accession | Q53GD3 |
|---|
| Gene | SLC44A4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 710 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (170)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.46
- deafness · score 0.37
- triglyceride measurement · score 0.35
- BMI-adjusted waist-hip ratio · score 0.33
- alcohol consumption measurement · score 0.32
- alcohol drinking · score 0.30
- wet macular degeneration · score 0.26
- chronotype measurement · score 0.26
- mosquito bite reaction itch intensity measurement · score 0.26
- forced expiratory volume · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GD3-F1 | alphafold | PREDICTED | 83.45 | — |
Amino-acid sequence (710 residues)
MGGKQRDEDD EAYGKPVKYD PSFRGPIKNR SCTDVICCVL FLLFILGYIV VGIVAWLYGD PRQVLYPRNS TGAYCGMGEN KDKPYLLYFN IFSCILSSNI ISVAENGLQC PTPQVCVSSC PEDPWTVGKN EFSQTVGEVF YTKNRNFCLP GVPWNMTVIT SLQQELCPSF LLPSAPALGR CFPWTNVTPP ALPGITNDTT IQQGISGLID SLNARDISVK IFEDFAQSWY WILVALGVAL VLSLLFILLL RLVAGPLVLV LILGVLGVLA YGIYYCWEEY RVLRDKGASI SQLGFTTNLS AYQSVQETWL AALIVLAVLE AILLLMLIFL RQRIRIAIAL LKEASKAVGQ MMSTMFYPLV TFVLLLICIA YWAMTALYLA TSGQPQYVLW ASNISSPGCE KVPINTSCNP TAHLVNSSCP GLMCVFQGYS SKGLIQRSVF NLQIYGVLGL FWTLNWVLAL GQCVLAGAFA SFYWAFHKPQ DIPTFPLISA FIRTLRYHTG SLAFGALILT LVQIARVILE YIDHKLRGVQ NPVARCIMCC FKCCLWCLEK FIKFLNRNAY IMIAIYGKNF CVSAKNAFML LMRNIVRVVV LDKVTDLLLF FGKLLVVGGV GVLSFFFFSG RIPGLGKDFK SPHLNYYWLP IMTSILGAYV IASGFFSVFG MCVDTLFLCF LEDLERNNGS LDRPYYMSKS LLKILGKKNE APPDNKKRKK
Explore Choline transporter-like protein 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets