PDZ and LIM domain protein 3 (PDLIM3)

About PDZ and LIM domain protein 3

PDZ and LIM domain protein 3 (PDLIM3) is a protein from Homo sapiens identified by UniProt accession Q53GG5, 364 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	PDZ and LIM domain protein 3
UniProt accession	Q53GG5
Gene	PDLIM3
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (199)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.21
dilated cardiomyopathy · score 0.21
type 2 diabetes mellitus · score 0.19
Abnormality of the cardiovascular system · score 0.16
genetic disorder · score 0.12
serum gamma-glutamyl transferase measurement · score 0.11
familial hypertrophic cardiomyopathy · score 0.11
left ventricular noncompaction · score 0.06
Arrhythmogenic right ventricular dysplasia · score 0.06
Sensorineural deafness with dilated cardiomyopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53GG5-F1	alphafold	PREDICTED	66.69	—

Amino-acid sequence (364 residues)

MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP FKINLESEPQ DGNYFEHKHN IRPKPFVIPG RSSGCSTPSG IDCGSGRSTP SSVSTVSTIC PGDLKVAAKL APNIPLEMEL PGVKIVHAQF NTPMQLYSDD NIMETLQGQV STALGETPLM SEPTASVPPE SDVYRMLHDN RNEPTQPRQS GSFRVLQGMV DDGSDDRPAG TRSVRAPVTK VHGGSGGAQR MPLCDKCGSG IVGAVVKARD KYRHPECFVC ADCNLNLKQK GYFFIEGELY CETHARARTK PPEGYDTVTL YPKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards