About Pleckstrin homology domain-containing family O member 1
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) is a protein
from Homo sapiens identified by UniProt accession
Q53GL0, 409 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family O member 1 |
|---|
| UniProt accession | Q53GL0 |
|---|
| Gene | PLEKHO1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 409 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neutrophil count · score 0.20
- granulocyte count · score 0.20
- schizophrenia · score 0.13
- mathematical ability · score 0.12
- bipolar disorder · score 0.12
- HbA1c measurement · score 0.11
- unipolar depression · score 0.10
- apolipoprotein A 1 measurement · score 0.10
- calcium measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GL0-F1 | alphafold | PREDICTED | 68.69 | — |
Amino-acid sequence (409 residues)
MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG DQLYISEKEV KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS KQPGNTAPNL IFLAVSPEEK ESWINALNSA ITRAKNRILD EVTVEEDSYL AHPTRDRAKI QHSRRPPTRG HLMAVASTST SDGMLTLDLI QEEDPSPEEP TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL SRPWEKTDKG ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ LLLETERLLG EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP HSQYRKSLM
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