About mRNA export factor GLE1
mRNA export factor GLE1 (GLE1) is a protein
from Homo sapiens identified by UniProt accession
Q53GS7, 698 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | mRNA export factor GLE1 |
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| UniProt accession | Q53GS7 |
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| Gene | GLE1 |
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| Organism | Homo sapiens |
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| Length | 698 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- Lethal arthrogryposis - anterior horn cell disease · score 0.73
- lethal arthrogryposis-anterior horn cell disease syndrome · score 0.72
- lethal congenital contracture syndrome 1 · score 0.63
- Lethal congenital contracture syndrome type 1 · score 0.46
- amyotrophic lateral sclerosis · score 0.41
- Amyotrophic lateral sclerosis · score 0.37
- genetic disorder · score 0.34
- neurodegenerative disease · score 0.32
- lethal congenital contracture syndrome · score 0.12
- pulse pressure measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GS7-F1 | alphafold | PREDICTED | 78.90 | — |
Amino-acid sequence (698 residues)
MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG WVVEHVLPHM QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP ATPNGTKGKD ESQHTESMVL QSSRGIKVEG CVRMYELVHR MKGTEGLRLW QEEQERKVQA LSEMASEQLK RFDEWKELKQ HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE GQIRLRALYA LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES SYPTAESQAE AERALREMRD LLMNLGQEIT RACEDKRRQD EEEAQVKLQE AQMQQGPEAH KEPPAPSQGP GGKQNEDLQV KVQDITMQWY QQLQDASMQC VLTFEGLTNS KDSQAKKIKM DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGDLI LAHLHKKCPY SVPFYPTFKE GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QEIHPHGLNH GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMLILIKE DYFPRIEAIT SSGQMGSFIR LKQFLEKCLQ HKDIPVPKGF LTSSFWRS
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