About Ubiquitin carboxyl-terminal hydrolase 39
Ubiquitin carboxyl-terminal hydrolase 39 (USP39) is a protein
from Homo sapiens identified by UniProt accession
Q53GS9, 565 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 39 |
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| UniProt accession | Q53GS9 |
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| Gene | USP39 |
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| Organism | Homo sapiens |
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| Length | 565 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.22
- chronic lymphocytic leukemia · score 0.15
- neurodegenerative disease · score 0.13
- lean body mass · score 0.12
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- platelet count · score 0.09
- esophageal squamous cell carcinoma · score 0.09
- myeloid white cell count · score 0.09
- body height · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GS9-F1 | alphafold | PREDICTED | 79.03 | — |
Amino-acid sequence (565 residues)
MSGRSKRESR GSTRGKRESE SRGSSGRVKR ERDREREPEA ASSRGSPVRV KREFEPASAR EAPASVVPFV RVKREREVDE DSEPEREVRA KNGRVDSEDR RSRHCPYLDT INRSVLDFDF EKLCSISLSH INAYACLVCG KYFQGRGLKS HAYIHSVQFS HHVFLNLHTL KFYCLPDNYE IIDSSLEDIT YVLKPTFTKQ QIANLDKQAK LSRAYDGTTY LPGIVGLNNI KANDYANAVL QALSNVPPLR NYFLEEDNYK NIKRPPGDIM FLLVQRFGEL MRKLWNPRNF KAHVSPHEML QAVVLCSKKT FQITKQGDGV DFLSWFLNAL HSALGGTKKK KKTIVTDVFQ GSMRIFTKKL PHPDLPAEEK EQLLHNDEYQ ETMVESTFMY LTLDLPTAPL YKDEKEQLII PQVPLFNILA KFNGITEKEY KTYKENFLKR FQLTKLPPYL IFCIKRFTKN NFFVEKNPTI VNFPITNVDL REYLSEEVQA VHKNTTYDLI ANIVHDGKPS EGSYRIHVLH HGTGKWYELQ DLQVTDILPQ MITLSEAYIQ IWKRRDNDET NQQGA
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