About Kelch-like protein 22
Kelch-like protein 22 (KLHL22) is a protein
from Homo sapiens identified by UniProt accession
Q53GT1, 634 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Kelch-like protein 22 |
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| UniProt accession | Q53GT1 |
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| Gene | KLHL22 |
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| Organism | Homo sapiens |
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| Length | 634 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.29
- clear cell renal carcinoma · score 0.18
- refractive error measurement · score 0.18
- type 2 diabetes mellitus · score 0.09
- complication · score 0.07
- early-onset non-syndromic cataract · score 0.06
- neoplasm · score 0.06
- isolated ectopia lentis · score 0.06
- Cataract-microcornea syndrome · score 0.06
- triple-negative breast cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53GT1-F1 | alphafold | PREDICTED | 89.55 | — |
Amino-acid sequence (634 residues)
MAEEQEFTQL CKLPAQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV QETLVAACQL QIPEIIHFCC DFLMSWVDEE NILDVYRLAE LFDLSRLTEQ LDTYILKNFV AFSRTDKYRQ LPLEKVYSLL SSNRLEVSCE TEVYEGALLY HYSLEQVQAD QISLHEPPKL LETVRFPLME AEVLQRLHDK LDPSPLRDTV ASALMYHRNE SLQPSLQSPQ TELRSDFQCV VGFGGIHSTP STVLSDQAKY LNPLLGEWKH FTASLAPRMS NQGIAVLNNF VYLIGGDNNV QGFRAESRCW RYDPRHNRWF QIQSLQQEHA DLSVCVVGRY IYAVAGRDYH NDLNAVERYD PATNSWAYVA PLKREVYAHA GATLEGKMYI TCGRRGEDYL KETHCYDPGS NTWHTLADGP VRRAWHGMAT LLNKLYVIGG SNNDAGYRRD VHQVACYSCT SGQWSSVCPL PAGHGEPGIA VLDNRIYVLG GRSHNRGSRT GYVHIYDVEK DCWEEGPQLD NSISGLAACV LTLPRSLLLE PPRGTPDRSQ ADPDFASEVM SVSDWEEFDN SSED
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