About Acylglycerol kinase, mitochondrial
Acylglycerol kinase, mitochondrial (AGK) is a protein
from Homo sapiens identified by UniProt accession
Q53H12, 422 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Acylglycerol kinase, mitochondrial |
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| UniProt accession | Q53H12 |
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| Gene | AGK |
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| Organism | Homo sapiens |
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| Length | 422 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- Sengers syndrome · score 0.80
- cataract 38 · score 0.73
- early-onset non-syndromic cataract · score 0.56
- cancer · score 0.55
- Congenital cataract - hypertrophic cardiomyopathy - mitochondrial myopathy · score 0.50
- genetic disorder · score 0.47
- Developmental cataract · score 0.42
- total early-onset cataract · score 0.37
- mitochondrial disease · score 0.37
- Syndromic diarrhea · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53H12-F1 | alphafold | PREDICTED | 86.97 | — |
Amino-acid sequence (422 residues)
MTVFFKTLRN HWKKTTAGLC LLTWGGHWLY GKHCDNLLRR AACQEAQVFG NQLIPPNAQV KKATVFLNPA ACKGKARTLF EKNAAPILHL SGMDVTIVKT DYEGQAKKLL ELMENTDVII VAGGDGTLQE VVTGVLRRTD EATFSKIPIG FIPLGETSSL SHTLFAESGN KVQHITDATL AIVKGETVPL DVLQIKGEKE QPVFAMTGLR WGSFRDAGVK VSKYWYLGPL KIKAAHFFST LKEWPQTHQA SISYTGPTER PPNEPEETPV QRPSLYRRIL RRLASYWAQP QDALSQEVSP EVWKDVQLST IELSITTRNN QLDPTSKEDF LNICIEPDTI SKGDFITIGS RKVRNPKLHV EGTECLQASQ CTLLIPEGAG GSFSIDSEEY EAMPVEVKLL PRKLQFFCDP RKREQMLTSP TQ
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