About Histone-lysine N-methyltransferase SETMAR
Histone-lysine N-methyltransferase SETMAR (SETMAR) is a protein
from Homo sapiens identified by UniProt accession
Q53H47, 684 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Histone-lysine N-methyltransferase SETMAR |
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| UniProt accession | Q53H47 |
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| Gene | SETMAR |
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| Organism | Homo sapiens |
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| Length | 684 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 15/16 · score 0.34
- PHF-tau measurement · score 0.13
- high density lipoprotein cholesterol measurement · score 0.09
- Abnormality of refraction · score 0.09
- Myopia · score 0.09
- refractive error · score 0.09
- age at onset · score 0.09
- metabolite measurement · score 0.07
- retinal vasculature measurement · score 0.06
- brain measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53H47-F1 | alphafold | PREDICTED | 82.81 | — |
Amino-acid sequence (684 residues)
MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP FQYTPDHVVG PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS CLRDIGSGGK YAEPVFECNV LCRCSDHCRN RVVQKGLQFH FQVFKTHKKG WGLRTLEFIP KGRFVCEYAG EVLGFSEVQR RIHLQTKSDS NYIIAIREHV YNGQVMETFV DPTYIGNIGR FLNHSCEPNL LMIPVRIDSM VPKLALFAAK DIVPEEELSY DYSGRYLNLT VSEDKERLDH GKLRKPCYCG AKSCTAFLPF DSSLYCPVEK SNISCGNEKE PSMCGSAPSV FPSCKRLTLE TMKMMLDKKQ IRAIFLFEFK MGRKAAETTR NINNAFGPGT ANERTVQWWF KKFCKGDESL EDEERSGRPS EVDNDQLRAI IEADPLTTTR EVAEELNVNH STVVRHLKQI GKVKKLDKWV PHELTENQKN RRFEVSSSLI LRNHNEPFLD RIVTCDEKWI LYDNRRRSAQ WLDQEEAPKH FPKPILHPKK VMVTIWWSAA GLIHYSFLNP GETITSEKYA QEIDEMNQKL QRLQLALVNR KGPILLHDNA RPHVAQPTLQ KLNELGYEVL PHPPYSPDLL PTNYHVFKHL NNFLQGKRFH NQQDAENAFQ EFVESQSTDF YATGINQLIS RWQKCVDCNG SYFD
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