Phospholipase A1 member A (PLA1A)

About Phospholipase A1 member A

Phospholipase A1 member A (PLA1A) is a protein from Homo sapiens identified by UniProt accession Q53H76, 456 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Phospholipase A1 member A
UniProt accession	Q53H76
Gene	PLA1A
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
melanoma · score 0.09
hepatocellular carcinoma · score 0.08
esophageal adenocarcinoma · score 0.05
neoplasm · score 0.04
immunodeficiency 51 · score 0.04
acne inversa, familial, 3 · score 0.04
gamma chain deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53H76-F1	alphafold	PREDICTED	89.63	—

Amino-acid sequence (456 residues)

MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK VQFLLFVPSN PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW IDTFIRTLLR ATNANVIAVD WIYGSTGVYF SAVKNVIKLS LEISLFLNKL LVLGVSESSI HIIGVSLGAH VGGMVGQLFG GQLGQITGLD PAGPEYTRAS VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ DQPGCPTFFY AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL RNKDTNIEVT FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK FQSSNRVWKK DRTTIIGKFC TALLPVNDRE KMVCLPEPVN LQASVTVSCD LKIACV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards