About Akirin-2
Akirin-2 (AKIRIN2) is a protein
from Homo sapiens identified by UniProt accession
Q53H80, 203 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Akirin-2 |
|---|
| UniProt accession | Q53H80 |
|---|
| Gene | AKIRIN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 203 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- cystatin C measurement · score 0.29
- diet measurement · score 0.14
- appendicular lean mass · score 0.12
- self reported educational attainment · score 0.10
- mathematical ability · score 0.09
- cholangiocarcinoma · score 0.07
- glioblastoma multiforme · score 0.07
- neoplasm · score 0.06
- monocyte percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53H80-F1 | alphafold | PREDICTED | 65.61 | — |
Amino-acid sequence (203 residues)
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPTSAAASP LSAAAATAAS FSAAAASPQK YLRMEPSPFG DVSSRLTTEQ ILYNIKQEYK RMQKRRHLET SFQQTDPCCT SDAQPHAFLL SGPASPGTSS AASSPLKKEQ PLFTLRQVGM ICERLLKERE EKVREEYEEI LNTKLAEQYD AFVKFTHDQI MRRYGEQPAS YVS
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