Pyrroline-5-carboxylate reductase 3 (PYCR3)

About Pyrroline-5-carboxylate reductase 3

Pyrroline-5-carboxylate reductase 3 (PYCR3) is a protein from Homo sapiens identified by UniProt accession Q53H96, 274 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Pyrroline-5-carboxylate reductase 3
UniProt accession	Q53H96
Gene	PYCR3
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.35
serum metabolite measurement · score 0.24
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
prostate cancer · score 0.11
HbA1c measurement · score 0.06
HMG CoA reductase inhibitor use measurement · score 0.06
schizophrenia · score 0.06
mean corpuscular hemoglobin concentration · score 0.05
serum alanine aminotransferase measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53H96-F1	alphafold	PREDICTED	94.82	—

Amino-acid sequence (274 residues)

MAAAEPSPRR VGFVGAGRMA GAIAQGLIRA GKVEAQHILA SAPTDRNLCH FQALGCRTTH SNQEVLQSCL LVIFATKPHV LPAVLAEVAP VVTTEHILVS VAAGVSLSTL EELLPPNTRV LRVLPNLPCV VQEGAIVMAR GRHVGSSETK LLQHLLEACG RCEEVPEAYV DIHTGLSGSG VAFVCAFSEA LAEGAVKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT TIYGLHALEQ GGLRAATMSA VEAATCRAKE LSRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards