About Kelch-like protein 26
Kelch-like protein 26 (KLHL26) is a protein
from Homo sapiens identified by UniProt accession
Q53HC5, 615 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Kelch-like protein 26 |
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| UniProt accession | Q53HC5 |
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| Gene | KLHL26 |
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| Organism | Homo sapiens |
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| Length | 615 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- gastroesophageal reflux disease · score 0.17
- PR interval · score 0.10
- peptic ulcer disease · score 0.09
- Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement · score 0.09
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.06
- diaphragmatic hernia · score 0.04
- esophageal disease · score 0.03
- metabolite measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53HC5-F1 | alphafold | PREDICTED | 91.28 | — |
Amino-acid sequence (615 residues)
MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL QGLATLRAQG QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS QDVIELKGVS ARGLRHIIDF AYSAEVTLDL DCVQDVLGAA VFLQMLPVVE LCEEFLKAAM SVETCLNIGQ MATTFSLASL RESVDAFTFR HFLQIAEEED FLRLPLERLV FFLQSNRLQS CAEIDLFRAA VRWLQHDPAR RPRASHVLCH IRFPLMQSSE LVDSVQTLDI MVEDVLCRQY LLEAFNYQVL PFRQHEMQSP RTAVRSDVPS LVTFGGTPYT DSDRSVSSKV YQLPEPGARH FRELTEMEVG CSHTCVAVLD NFVYVAGGQH LQYRSGEGAV DACYRYDPHL NRWLRLQAMQ ESRIQFQLNV LCGMVYATGG RNRAGSLASV ERYCPRRNEW GYACSLKRRT WGHAGAASGG RLYISGGYGI SVEDKKALHC YDPVADQWEF KAPMSEPRVL HAMVGAGGRI YALGGRMDHV DRCFDVLAVE YYVPETDQWT SVSPMRAGQS EAGCCLLERK IYIVGGYNWR LNNVTGIVQV YNTDTDEWER DLHFPESFAG IACAPVLLPR AGTRR
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