EARP and GARP complex-interacting protein 1 (EIPR1)

About EARP and GARP complex-interacting protein 1

EARP and GARP complex-interacting protein 1 (EIPR1) is a protein from Homo sapiens identified by UniProt accession Q53HC9, 387 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	EARP and GARP complex-interacting protein 1
UniProt accession	Q53HC9
Gene	EIPR1
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.27
cognitive decline measurement · score 0.24
protein measurement · score 0.24
Abnormality of refraction · score 0.15
Lobular Breast Carcinoma In Situ · score 0.14
insomnia measurement · score 0.14
neuroticism measurement · score 0.12
mental or behavioural disorder · score 0.11
Blackfan-Diamond anemia · score 0.09
primary familial polycythemia due to EPO receptor mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53HC9-F1	alphafold	PREDICTED	89.14	—

Amino-acid sequence (387 residues)

MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR MPKELESGSH ESPDDSSSTA QTLELLCHLD NTAHGNMACV VWEPMGDGKK IISLADNHIL LWDLQESSSQ AVLASSASLE GKGQLKFTSG RWSPHHNCTQ VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK QYYLASCGDD CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV YAVDWSSADP WLFASLSYDG RLVINRVPRA LKYHILL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards