About Borealin
Borealin (CDCA8) is a protein
from Homo sapiens identified by UniProt accession
Q53HL2, 280 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Borealin |
|---|
| UniProt accession | Q53HL2 |
|---|
| Gene | CDCA8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- Neutrophil inclusion bodies · score 0.26
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.21
- atrophy of thyroid · score 0.19
- congenital hypothyroidism · score 0.19
- esophageal cancer · score 0.14
- hepatocellular carcinoma · score 0.12
- breast cancer · score 0.10
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53HL2-F1 | alphafold | PREDICTED | 67.96 | — |
Amino-acid sequence (280 residues)
MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD EMIVEEEEEE ENERKNLQTA RVKRCPPSKK RTQSIQGKGK GKRSSRANTV TPAVGRLEVS MVKPTPGLTP RFDSRVFKTP GLRTPAAGER IYNISGNGSP LADSKEIFLT VPVGGGESLR LLASDLQRHS IAQLDPEALG NIKKLSNRLA QICSSIRTHK
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