Rho GTPase-activating protein 15 (ARHGAP15)

About Rho GTPase-activating protein 15

Rho GTPase-activating protein 15 (ARHGAP15) is a protein from Homo sapiens identified by UniProt accession Q53QZ3, 475 residues long. MolForge cross-references it against 0 known binders and 249 disease associations.

Target properties

Protein name	Rho GTPase-activating protein 15
UniProt accession	Q53QZ3
Gene	ARHGAP15
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (249)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.50
mean platelet volume · score 0.49
eosinophil count · score 0.48
leukocyte count · score 0.48
body mass index · score 0.47
platelet count · score 0.46
lymphocyte percentage of leukocytes · score 0.46
platelet component distribution width · score 0.46
neutrophil percentage of leukocytes · score 0.46
myeloid white cell count · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53QZ3-F1	alphafold	PREDICTED	76.05	—

Amino-acid sequence (475 residues)

MQKSTNSDTS VETLNSTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG KVTEPISRHR RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK NWSTSWIVLS SRRIEFYKES KQQALSNMKT GHKPESVDLC GAHIEWAKEK SSRKNVFQIT TVSGNEFLLQ SDIDFIILDW FHAIKNAIDR LPKDSSCPSR NLELFKIQRS SSTELLSHYD SDIKEQKPEH RKSLMFRLHH SASDTSDKNR VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHKVCERE NSTVPWFVKQ CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV VTGALKMFFR ELPEPLFPYS FFEQFVEAIK KQDNNTRIEA VKSLVQKLPP PNRDTMKVLF GHLTKIVAKA SKNLMSTQSL GIVFGPTLLR AENETGNMAI HMVYQNQIAE LMLSEYSKIF GSEED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards