Retroviral-like aspartic protease 1 (ASPRV1)

About Retroviral-like aspartic protease 1

Retroviral-like aspartic protease 1 (ASPRV1) is a protein from Homo sapiens identified by UniProt accession Q53RT3, 343 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Retroviral-like aspartic protease 1
UniProt accession	Q53RT3
Gene	ASPRV1
Organism	Homo sapiens
Length	343 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

ichthyosis, lamellar, autosomal dominant · score 0.59
lamellar ichthyosis · score 0.37
vital capacity · score 0.32
genetic disorder · score 0.19
mean corpuscular volume · score 0.13
high density lipoprotein cholesterol measurement · score 0.12
mean platelet volume · score 0.11
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53RT3-F1	alphafold	PREDICTED	69.71	—

Amino-acid sequence (343 residues)

MGSPGASLGI KKALQSEQAT ALPASAPAVS QPTAPAPSCL PKAGQVIPTL LREAPFSSVI APTLLCGFLF LAWVAAEVPE ESSRMAGSGA RSEEGRRQHA FVPEPFDGAN VVPNLWLHSF EVINDLNHWD HITKLRFLKE SLRGEALGVY NRLSPQDQGD YGTVKEALLK AFGVPGAAPS HLPKEIVFAN SMGKGYYLKG KIGKVPVRFL VDSGAQVSVV HPNLWEEVTD GDLDTLQPFE NVVKVANGAE MKILGVWDTA VSLGKLKLKA QFLVANASAE EAIIGTDVLQ DHNAILDFEH RTCTLKGKKF RLLPVGGSLE DEFDLELIEE DPSSEEGRQE LSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards