About Keratinocyte-associated protein 3
Keratinocyte-associated protein 3 (KRTCAP3) is a protein
from Homo sapiens identified by UniProt accession
Q53RY4, 240 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Keratinocyte-associated protein 3 |
|---|
| UniProt accession | Q53RY4 |
|---|
| Gene | KRTCAP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 240 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (141)
Diseases linked to this target (Open Targets).
- short-rib thoracic dysplasia 10 with or without polydactyly · score 0.55
- retinitis pigmentosa 71 · score 0.55
- Bardet-Biedl syndrome 20 · score 0.50
- retinitis pigmentosa · score 0.34
- age at menopause · score 0.20
- genetic disorder · score 0.19
- Retinal dystrophy · score 0.18
- triglyceride measurement · score 0.15
- hair color · score 0.15
- type 2 diabetes mellitus · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53RY4-F1 | alphafold | PREDICTED | 76.46 | — |
Amino-acid sequence (240 residues)
MRRCSLCAFD AARGPRRLMR VGLALILVGH VNLLLGAVLH GTVLRHVANP RGAVTPEYTV ANVISVGSGL LSVSVGLVAL LASRNLLRPP LHWVLLALAL VNLLLSVACS LGLLLAVSLT VANGGRRLIA DCHPGLLDPL VPLDEGPGHT DCPFDPTRIY DTALALWIPS LLMSAGEAAL SGYCCVAALT LRGVGPCRKD GLQGQLEEMT ELESPKCKRQ ENEQLLDQNQ EIRASQRSWV
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