Cordon-bleu protein-like 1 (COBLL1)

About Cordon-bleu protein-like 1

Cordon-bleu protein-like 1 (COBLL1) is a protein from Homo sapiens identified by UniProt accession Q53SF7, 1128 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Cordon-bleu protein-like 1
UniProt accession	Q53SF7
Gene	COBLL1
Organism	Homo sapiens
Length	1128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.48
sex hormone-binding globulin measurement · score 0.47
high density lipoprotein cholesterol measurement · score 0.47
reticulocyte count · score 0.45
body mass index · score 0.45
waist-hip ratio · score 0.45
triglyceride measurement · score 0.45
BMI-adjusted waist circumference · score 0.41
serum albumin measurement · score 0.41
type 2 diabetes mellitus · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53SF7-F1	alphafold	PREDICTED	50.23	—

Amino-acid sequence (1128 residues)

MDGRTPRPQD APARRKPKAK APLPPAETKY TDVSSAADSV ESTAFIMEQK ENMIDKDVEL SVVLPGDIIK STTVHGSKPM MDLLIFLCAQ YHLNPSSYTI DLLSAEQNHI KFKPNTPIGM LEVEKVILKP KMLDKKKPTP IIPEKTVRVV INFKKTQKTI VRVSPHASLQ ELAPIICSKC EFDPLHTLLL KDYQSQEPLD LTKSLNDLGL RELYAMDVNR ESCQISQNLD IMKEKENKGF FSFFQRSKKK RDQTASAPAT PLVNKHRPTF TRSNTISKPY ISNTLPSDAP KKRRAPLPPM PASQSVPQDL AHIQERPASC IVKSMSVDET DKSPCEAGRV RAGSLQLSSM SAGNSSLRRT KRKAPSPPSK IPPHQSDENS RVTALQPVDG VPPDSASEAN SPEELSSPAG ISSDYSLEEI DEKEELSEVP KVEAENISPK SQDIPFVSTD IINTLKNDPD SALGNGSGEF SQNSMEEKQE TKSTDGQEPH SVVYDTSNGK KVVDSIRNLK SLGPNQENVV QNEIIVYPEN TEDNMKNGVK KTEINVEGVA KNNNIDMEVE RPSNSEAHET DTAISYKENH LAASSVPDQK LNQPSAEKTK DAAIQTTPSC NSFDGKHQDH NLSDSKVEEC VQTSNNNIST QHSCLSSQDS VNTSREFRSQ GTLIIHSEDP LTVKDPICAH GNDDLLPPVD RIDKNSTASY LKNYPLYRQD YNPKPKPSNE ITREYIPKIG MTTYKIVPPK SLEISKDWQS ETIEYKDDQD MHALGKKHTH ENVKETAIQT EDSAISESPE EPLPNLKPKP NLRTEHQVPS SVSSPDDAMV SPLKPAPKMT RDTGTAPFAP NLEEINNILE SKFKSRASNA QAKPSSFFLQ MQKRVSGHYV TSAAAKSVHA APNPAPKELT NKEAERDMLP SPEQTLSPLS KMPHSVPQPL VEKTDDDVIG QAPAEASPPP IAPKPVTIPA SQVSTQNLKT LKTFGAPRPY SSSGPSPFAL AVVKRSQSFS KERTESPSAS ALVQPPANTE EGKTHSVNKF VDIPQLGVSD KENNSAHNEQ NSQIPTPTDG PSFTVMRQSS LTFQSSDPEQ MRQSLLTAIR SGEAAAKLKR VTIPSNTISV NGRSRLSHSM SPDAQDGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards