HCLS1-binding protein 3 (HS1BP3)

About HCLS1-binding protein 3

HCLS1-binding protein 3 (HS1BP3) is a protein from Homo sapiens identified by UniProt accession Q53T59, 392 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	HCLS1-binding protein 3
UniProt accession	Q53T59
Gene	HS1BP3
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

hematocrit · score 0.30
hemoglobin measurement · score 0.29
red blood cell density measurement · score 0.13
HMG CoA reductase inhibitor use measurement · score 0.12
low density lipoprotein cholesterol measurement · score 0.09
systolic blood pressure · score 0.05
prostate carcinoma · score 0.04
alcohol drinking · score 0.04
pulse pressure measurement · score 0.03
sex hormone-binding globulin measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53T59-F1	alphafold	PREDICTED	66.64	—

Amino-acid sequence (392 residues)

MQSPAVLVTS RRLQNAHTGL DLTVPQHQEV RGKMMSGHVE YQILVVTRLA AFKSAKHRPE DVVQFLVSKK YSEIEEFYQK LSSRYAAASL PPLPRKVLFV GESDIRERRA VFNEILRCVS KDAELAGSPE LLEFLGTRSP GAAGLTSRDS SVLDGTDSQT GNDEEAFDFF EEQDQVAEEG PPVQSLKGED AEESLEEEEA LDPLGIMRSK KPKKHPKVAV KAKPSPRLTI FDEEVDPDEG LFGPGRKLSP QDPSEDVSSV DPLKLFDDPD LGGAIPLGDS LLLPAACESG GPTPSLSHRD ASKELFRVEE DLDQILNLGA EPKPKPQLKP KPPVAAKPVI PRKPAVPPKA GPAEAVAGQQ KPQEQIQAMD EMDILQYIQD HDTPAQAAPS LF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards