About INO80 complex subunit D
INO80 complex subunit D (INO80D) is a protein
from Homo sapiens identified by UniProt accession
Q53TQ3, 1027 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | INO80 complex subunit D |
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| UniProt accession | Q53TQ3 |
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| Gene | INO80D |
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| Organism | Homo sapiens |
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| Length | 1027 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.41
- BMI-adjusted waist circumference · score 0.38
- reticulocyte count · score 0.37
- neurodegenerative disease · score 0.37
- daytime rest measurement · score 0.30
- BMI-adjusted waist-hip ratio · score 0.30
- smoking status measurement · score 0.30
- alcohol consumption measurement · score 0.30
- mean corpuscular volume · score 0.24
- vertebral joint disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53TQ3-F1 | alphafold | PREDICTED | 51.51 | — |
Amino-acid sequence (1027 residues)
MYEGKHIHFS EVDNKPLCSY SPKLCKQRRL NGYAFCIRHV LEDKTAPFKQ CEYVAKYNSQ RCTNPIPKSE DRRYCNSHLQ VLGFIPKKER KKKNDPIDEV KVRHQMDTMA FSLTVPTLAL KMPNGLDGMS LSPPGARVPL HYLETELEDP FAFNEEDDDL KKGATVRKKL QSKLAQNRQR QRETEILKVR QEHFSPPPAP SQQQPPQQHS HLSPLSTSLK PPAPPQGSVC KSPQPQNTSL PMQGVAPTTH TIAQARQLSH KRPLPLLPSS RAPTVDPPRT DRILMKATAF SPHFSCISRL QRLVKLCTQK HQLDTDLFPH LGLDWSEESG EEPEDSEQAS PYQVAWSIRE TLRYQRHASD DDDAESRSSR VTQLCTYFQQ KYKHLCRLER AESRQKKCRH TFRKALLQAA SKEPECTGQL IQELRRAACS RTSISRTKLR EVEPAACSGT VKGEQCANKA LPFTRHCFQH ILLNHSQQLF SSCTAKFADG QQCSVPVFDI THQTPLCEEH AKKMDNFLRG DNSRKVQHQQ QRKPRKKTKP PALTKKHKKK RRRGPRRPQK PIPPAVPQGN LSMPASVSLP VEASHIRSPS TPELSADELP DDIANEITDI PHDLELNQED FSDVLPRLPD DLQDFDFFEG KNGDLLPTTE EAEELERALQ AVTSLECLST IGVLAQSDGV PVQELSDRGI GVFSTGTGAS GIQSLSREVN TDLGELLNGR IVHDNFSSLE LDENLLRSAT LSNPPTPLAG QIQGQFSAPA NVGLTSATLI SQSALGERAF PGQFHGLHDG SHASQRPHPA QLLSKADDLI TSRQQYSSDH SHSSPHGSHY DSEHVPSPYS DHITSPHTTS YSGDNMAATF SAEMPIMAQH LLPTQLEVPL GGVVNPRTHW GNLPVNLGDP SPFSNLLGAD GHLLSTSLST PPTTSNSETT QPAFATVTPS SSSVLPGLPQ TSFSGMGPSA ELMASTSPKQ QLPQFSAAFG HQLSSHSGIP KDLQPSHSSI APPTGFTVTG ATATSTNNAS SPFPSPN
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