About Cation channel sperm-associated targeting subunit tau
Cation channel sperm-associated targeting subunit tau (CATSPERT) is a protein
from Homo sapiens identified by UniProt accession
Q53TS8, 1820 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Cation channel sperm-associated targeting subunit tau |
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| UniProt accession | Q53TS8 |
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| Gene | CATSPERT |
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| Organism | Homo sapiens |
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| Length | 1820 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.38
- platelet crit · score 0.19
- body height · score 0.19
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 72 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53TS8-F1 | alphafold | PREDICTED | 39.65 | — |
Amino-acid sequence (1820 residues)
MEPPQETNRP FSTLDNRSGQ VQVLSATPLL QRNPYSSPDI MHIKGSEASS VPYALNQGTT ALPKNKNQEG TGHRLLNMLR KTLKESDSEE LEITQETPNL VPFGDVVGCL GIHIKNCRHF MPKISLQHYA NLFIRISINK AVKCTKMCSL LSKNDEKNTV IKFDEVKYFS VQVPRRYDDK RNNILLELIQ YDNREKRAFL LGSVQIHLYE VIQKGCFIEE VQVLHGNIFV CRLEVEFMFS YGNFGYGFSH QLKPLQKITE PSMFMNLAPP PERTDPVTKV ITPQTVEYPA FLSPDLNVTV GTPAVQSSNQ PSVVRLEKLQ QQPRERLEKM KKEYRNLNTW IDKANYLESI LMPKLEHKDS EETNIDEASE NTKSNHPEEE LENIVGVDIP LVNEEAETTA NELLDNDSEK GLTIPTLNQS DQDNSTADAS KNDESTPSPT EVHSLCTISN QETIKAGRIP PLGERQSESM PDRKMKNVFF PLEVKLKDNY PSILKADSSL SEVAFSPKEY NSPSFRPEYI EFKPKFQFQK FNKNGFDPFL RNINKMSVRK RKDQDIYKYR NILGAEVIEH EDQDPPYPAQ SKTAGPANTT WAHDPNIFTT KMLETENKLA PDPTINTIKG LDTKNSLKEN LPNVSLPSIK GESSRAGNVQ ANTCHLSKSL NFTPHIEYLK QSMILKSILS ENLQDLSDKL FSKPEVSMNS EAREKSSSPL LSIHDKSSSS MEDNVLEKKQ DLNNWLSEKD ILNSKTTLSQ IIKNIPADSF SEGSQIIENI PADSLLEGGQ VIKNIPEYSL SEGGQIIKNI PADSFLESGP GQSPEVEEHV SKKHFEADER DFPIKKNSST KKKHLISEVP NSKSGSSGTV HDYIMRQIFT APIFSELEIE VKEPSETPMN LENQLPTPWK RSLSSHILFH EENADEIELP QPRSATSQII QAFPIDTLLE SGIIKVIELD KEHHKSSLLG TGITSPKGNL KDSQEYYSEI RSETEPLSEQ SIPIIPKDTT SVSRAEFIQE DQNMFPQDSS YYSIANKELY LPRNGQRLCK DKNDLSSTLE SLTNSLMDKL SESDEIMLKS FLKNIFNVFF KYNHSERRGQ PEKELERLIQ PSFTSDTEHL EELQEDFDKA DKLDRKPILS PKLRVFLEEL SESEVKHLKS ELSKQIQHYL VERLSESGHI TKEDLPKIYQ NLYLMNEKAE QKGPNSFQGK YSETVKEIMS FVNNFNHHFI DKHLEIKLRS FLKEILQNYF LKNISESSLF NETASETIYP NISSLRTKSV SISFHELEQD ISKGSFGRRF EINMKYPLSK SLQNYLIALS ENELLHLKAD LSKHLQSLFI EKLSKSGLMT KKQLEGINQH INLLNSSSIP LKYIKTHLPF RDDCHFVEKH SEKQNKYSRI VQQTTLQTVS EDKLREAELI REKEKKYFPL QNLKGNSSLI KEQKSYYTKE EAKTPSLIKV QPSSNENIQA SPLSKSSEIL TDILLKKLRK EHVFTQLPQA ENSVHKTEIQ DPYSWGGKSK ITQSKAWCEK TLKMKSLDRK EHVNIYKWTV QEKPEAVLTS YPRIPNARMP REDEYLNRIT FPSWQSSTLT HFNTETGEKS KLEDQYCQTL KGNNNNNKKH LVTFAQYKKE IQTLYIKPDE ICSEKCAKFP EIQSFQYKVV EDEKNLKPHL FPELFKIEDL KPKVRKERDR VAQPKKSFNK IVRILPTTLP TTRIHLKKSV PRTLLHWTAR RTIHDCSDKF EDLHDMTSFT HLKKVKSRSR LLGKSSDDIH NHARHSARPY TAPEVNKQRE SYSGKFTSRR MVSSGLVHIN DKTSDYEMHK MRPKKIKRGY
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