Beta-actin-like protein 2 (ACTBL2)

About Beta-actin-like protein 2

Beta-actin-like protein 2 (ACTBL2) is a protein from Homo sapiens identified by UniProt accession Q562R1, 376 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Beta-actin-like protein 2
UniProt accession	Q562R1
Gene	ACTBL2
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.36
mathematical ability · score 0.29
cognitive function measurement · score 0.26
schizophrenia · score 0.26
intelligence · score 0.25
body mass index · score 0.25
hypertrophic cardiomyopathy · score 0.24
FEV/FVC ratio · score 0.22
neutrophil count · score 0.18
balding measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q562R1-F1	alphafold	PREDICTED	94.84	—

Amino-acid sequence (376 residues)

MTDNELSALV VDNGSGMCKA GFGGDDAPRA VFPSMIGRPR HQGVMVGMGQ KDCYVGDEAQ SKRGVLTLKY PIEHGVVTNW DDMEKIWYHT FYNELRVAPD EHPILLTEAP LNPKINREKM TQIMFEAFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV THIVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYN FTTTAEREIV RDVKEKLCYV ALDFEQEMVR AAASSSPERS YELPDGQVIT IGNERFRCPE AIFQPSFLGI ESSGIHETTF NSIMKCDVDI RKDLYANTVL SGGSTMYPGI ADRMQKEIIT LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK QEYDEAGPPI VHRKCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards