About N-acetyltransferase ESCO2
N-acetyltransferase ESCO2 (ESCO2) is a protein
from Homo sapiens identified by UniProt accession
Q56NI9, 601 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | N-acetyltransferase ESCO2 |
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| UniProt accession | Q56NI9 |
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| Gene | ESCO2 |
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| Organism | Homo sapiens |
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| Length | 601 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- Roberts-SC phocomelia syndrome · score 0.84
- Juberg-Hayward syndrome · score 0.62
- genetic disorder · score 0.45
- body height · score 0.19
- acute myeloid leukemia · score 0.18
- endometrial cancer · score 0.14
- erythrocyte count · score 0.13
- hereditary breast ovarian cancer syndrome · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- glioblastoma multiforme · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q56NI9-F1 | alphafold | PREDICTED | 58.39 | — |
Amino-acid sequence (601 residues)
MAALTPRKRK QDSLKCDSLL HFTENLFPSP NKKHCFYQNS DKNEENLHCS QQEHFVLSAL KTTEINRLPS ANQGSPFKSA LSTVSFYNQN KWYLNPLERK LIKESRSTCL KTNDEDKSFP IVTEKMQGKP VCSKKNNKKP QKSLTAKYQP KYRHIKPVSR NSRNSKQNRV IYKPIVEKEN NCHSAENNSN APRVLSQKIK PQVTLQGGAA FFVRKKSSLR KSSLENEPSL GRTQKSKSEV IEDSDVETVS EKKTFATRQV PKCLVLEEKL KIGLLSASSK NKEKLIKDSS DDRVSSKEHK VDKNEAFSSE DSLGENKTIS PKSTVYPIFS ASSVNSKRSL GEEQFSVGSV NFMKQTNIQK NTNTRDTSKK TKDQLIIDAG QKHFGATVCK SCGMIYTASN PEDEMQHVQH HHRFLEGIKY VGWKKERVVA EFWDGKIVLV LPHDPSFAIK KVEDVQELVD NELGFQQVVP KCPNKIKTFL FISDEKRVVG CLIAEPIKQA FRVLSEPIGP ESPSSTECPR AWQCSDVPEP AVCGISRIWV FRLKRRKRIA RRLVDTLRNC FMFGCFLSTD EIAFSDPTPD GKLFATKYCN TPNFLVYNFN S
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