About Putative ATP-dependent RNA helicase TDRD12
Putative ATP-dependent RNA helicase TDRD12 (TDRD12) is a protein
from Homo sapiens identified by UniProt accession
Q587J7, 1177 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Putative ATP-dependent RNA helicase TDRD12 |
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| UniProt accession | Q587J7 |
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| Gene | TDRD12 |
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| Organism | Homo sapiens |
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| Length | 1177 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (129)
Diseases linked to this target (Open Targets).
- male infertility · score 0.40
- neurodegenerative disease · score 0.32
- hemoglobin measurement · score 0.30
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin concentration · score 0.15
- hematocrit · score 0.10
- azoospermia · score 0.10
- creatinine measurement · score 0.10
- breast adenocarcinoma · score 0.09
- partial chromosome Y deletion · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q587J7-F1 | alphafold | PREDICTED | 73.14 | — |
Amino-acid sequence (1177 residues)
MLQLLVLKIE DPGCFWVIIK GCSPFLDHDV DYQKLNSAMN DFYNSTCQDI EIKPLTLEEG QVCVVYCEEL KCWCRAIVKS ITSSADQYLA ECFLVDFAKN IPVKSKNIRV VVESFMQLPY RAKKFSLYCT KPVTLHIDFC RDSTDIVPAK KWDNAAIQYF QNLLKATTQV EARLCAVEED TFEVYLYVTI KDEKVCVNDD LVAKNYACYM SPTKNKNLDY LEKPRLNIKS APSFNKLNPA LTLWPMFLQG KDVQGMEDSH GVNFPAQSLQ HTWCKGIVGD LRPTATAQDK AVKCNMDSLR DSPKDKSEKK HHCISLKDTN KRVESSVYWP AKRGITIYAD PDVPEASALS QKSNEKPLRL TEKKEYDEKN SCVKLLQFLN PDPLRADGIS DLQQLQKLKG LQPPVVVLRN KIKPCLTIDS SPLSADLKKA LQRNKFPGPS HTESYSWPPI ARGCDVVVIS HCESNPLLYL LPVLTVLQTG ACYKSLPSRN GPLAVIVCPG WKKAQFIFEL LGEYSMSSRP LHPVLLTIGL HKEEAKNTKL PRGCDVIVTT PYSLLRLLAC QSLLFLRLCH LILDEVEVLF LEANEQMFAI LDNFKKNIEV EERESAPHQI VAVGVHWNKH IEHLIKEFMN DPYIVITAME EAALYGNVQQ VVHLCLECEK TSSLLQALDF IPSQAQKTLI FTCSVAETEI VCKVVESSSI FCLKMHKEMI FNLQNVLEQW KKKLSSGSQI ILALTDDCVP LLAITDATCV IHFSFPASPK VFGGRLYCMS DHFHAEQGSP AEQGDKKAKS VLLLTEKDAS HAVGVLRYLE RADAKVPAEL YEFTAGVLEA KEDKKAGRPL CPYLKAFGFC KDKRICPDRH RINPETDLPR KLSSQALPSF GYIKIIPFYI LNATNYFGRI VDKHMDLYAT LNAEMNEYFK DSNKTTVEKV EKFGLYGLAE KTLFHRVQVL EVNQKEDAWA LDDILVEFID EGRTGLVTRD QLLHLPEHFH TLPPQAVEFI VCRVKPADNE IEWNPKVTRY IHHKIVGKLH DAKVILALGN TVWIDPMVHI TNLSSLKTSV IDYNVRAEIL SMGMGIDNPE HIEQLKKLRE DAKIPACEES LSQTPPRVTG TSPAQDQDHP SEEQGGQGTP PAEDAACLQS PQPEDTGAEG GAESKTSSEN QKPGGYLVFK RWLSSNR
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