About KH domain-containing protein 3
KH domain-containing protein 3 (KHDC3L) is a protein
from Homo sapiens identified by UniProt accession
Q587J8, 217 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | KH domain-containing protein 3 |
|---|
| UniProt accession | Q587J8 |
|---|
| Gene | KHDC3L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- Hydatidiform Mole · score 0.70
- complete hydatidiform mole · score 0.37
- genetic disorder · score 0.19
- Posterior Leukoencephalopathy Syndrome · score 0.03
- ovarian dysfunction · score 0.02
- Down syndrome · score 0.02
- Autoimmune polyendocrinopathy type 1 · score 0.01
- nervous system disease · score 0.01
- Haim-Munk syndrome · score 0.01
- melanocytic nevus · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q587J8-F1 | alphafold | PREDICTED | 66.66 | — |
Amino-acid sequence (217 residues)
MDAPRRFPTL VQLMQPKAMP VEVLGHLPKR FSWFHSEFLK NPKVVRLEVW LVEKIFGRGG ERIPHVQGMS QILIHVNRLD PNGEAEILVF GRPSYQEDTI KMIMNLADYH RQLQAKGSGK ALAQDVATQK AETQRSSIEV REAGTQRSVE VREAGTQRSV EVQEVGTQGS PVEVQEAGTQ QSLQAANKSG TQRSPEAASK AVTQRFREDA RDPVTRL
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