About PAN2-PAN3 deadenylation complex subunit PAN3
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) is a protein
from Homo sapiens identified by UniProt accession
Q58A45, 887 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | PAN2-PAN3 deadenylation complex subunit PAN3 |
|---|
| UniProt accession | Q58A45 |
|---|
| Gene | PAN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 887 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.49
- mean corpuscular volume · score 0.49
- neurodegenerative disease · score 0.46
- mean corpuscular hemoglobin · score 0.45
- mean corpuscular hemoglobin concentration · score 0.45
- monocyte percentage of leukocytes · score 0.42
- age at menarche · score 0.34
- granulocyte percentage of myeloid white cells · score 0.34
- platelet crit · score 0.32
- adolescent idiopathic scoliosis · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q58A45-F1 | alphafold | PREDICTED | 62.68 | — |
Amino-acid sequence (887 residues)
MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR YYAKDKTCFY GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP GAVAGGGAGP PPGPKKPDLG DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG ALTDTSLTDS YFSTSFIGVN GFGSPVETKY PLMQRMTNSS SSPSLLNDSA KPYSAHDPLT SPASSLFNDF GALNISQRRK PRKYRLGMLE ERLVPMGSKA RKAKNPIGCL ADRCKSGVPI NMVWWNRVTE NNLQTPNPTA SEFIPKGGST SRLSNVSQSN MSAFSQVFSH PSMGSPATAG LAPGMSLSAG SSPLHSPKIT PHTSPAPRRR SHTPNPASYM VPSSASTSVN NPVSQTPSSG QVIQKETVGG TTYFYTDTTP APLTGMVFPN YHIYPPTAPH VAYMQPKANA PSFFMADELR QELINRHLIT MAQIDQADMP AVPTEVDSYH SLFPLEPLPP PNRIQKSSNF GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW KKIQHSNIVT LREVFTTKAF AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH EGPLPRQHAG LLPESLIWAY IVQLSSALRT IHTAGLACRV MDPTKILITG KTRLRVNCVG VFDVLTFDNS QNNNPLALMA QYQQADLISL GKVVLALACN SLAGIQRENL QKAMELVTIN YSSDLKNLIL YLLTDQNRMR SVNDIMPMIG ARFYTQLDAA QMRNDVIEED LAKEVQNGRL FRLLAKLGTI NERPEFQKDP TWSETGDRYL LKLFRDHLFH QVTEAGAPWI DLSHIISCLN KLDAGVPEKI SLISRDEKSV LVVTYSDLKR CFENTFQELI AAANGQL
Explore PAN2-PAN3 deadenylation complex subunit PAN3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets