About Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADL2) is a protein
from Homo sapiens identified by UniProt accession
Q58DX5, 795 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 |
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| UniProt accession | Q58DX5 |
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| Gene | NAALADL2 |
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| Organism | Homo sapiens |
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| Length | 795 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- risky sexual behaviour measurement · score 0.32
- bone density · score 0.32
- urate measurement · score 0.32
- self reported educational attainment · score 0.29
- neurofibrillary tangles measurement · score 0.28
- smoking status measurement · score 0.25
- diet measurement · score 0.25
- wellbeing measurement · score 0.22
- attention deficit hyperactivity disorder · score 0.20
- antisocial behaviour measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q58DX5-F1 | alphafold | PREDICTED | 78.74 | — |
Amino-acid sequence (795 residues)
MGENEASLPN TSLQGKKMAY QKVHADQRAP GHSQYLDNDD LQATALDLEW DMEKELEESG FDQFQLDGAE NQNLGHSETI DLNLDSIQPA TSPKGRFQRL QEESDYITHY TRSAPKSNRC NFCHVLKILC TATILFIFGI LIGYYVHTNC PSDAPSSGTV DPQLYQEILK TIQAEDIKKS FRNLVQLYKN EDDMEISKKI KTQWTSLGLE DVQFVNYSVL LDLPGPSPST VTLSSSGQCF HPNGQPCSEE ARKDSSQDLL YSYAAYSAKG TLKAEVIDVS YGMADDLKRI RKIKNVTNQI ALLKLGKLPL LYKLSSLEKA GFGGVLLYID PCDLPKTVNP SHDTFMVSLN PGGDPSTPGY PSVDESFRQS RSNLTSLLVQ PISAPLVAKL ISSPKARTKN EACSSLELPN NEIRVVSMQV QTVTKLKTVT NVVGFVMGLT SPDRYIIVGS HHHTAHSYNG QEWASSTAII TAFIRALMSK VKRGWRPDRT IVFCSWGGTA FGNIGSYEWG EDFKKVLQKN VVAYISLHSP IRGNSSLYPV ASPSLQQLVV EKNNFNCTRR AQCPETNISS IQIQGDADYF INHLGVPIVQ FAYEDIKTLE GPSFLSEARF STRATKIEEM DPSFNLHETI TKLSGEVILQ IANEPVLPFN ALDIALEVQN NLKGDQPNTH QLLAMALRLR ESAELFQSDE MRPANDPKER APIRIRMLND ILQDMEKSFL VKQAPPGFYR NILYHLDEKT SRFSILIEAW EHCKPLASNE TLQEALSEVL NSINSAQVYF KAGLDVFKSV LDGKN
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