Acyl-CoA wax alcohol acyltransferase 1 (AWAT1)

About Acyl-CoA wax alcohol acyltransferase 1

Acyl-CoA wax alcohol acyltransferase 1 (AWAT1) is a protein from Homo sapiens identified by UniProt accession Q58HT5, 328 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Acyl-CoA wax alcohol acyltransferase 1
UniProt accession	Q58HT5
Gene	AWAT1
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.11
Brugada syndrome · score 0.09
familial atrial fibrillation · score 0.08
Romano-Ward syndrome · score 0.08
Familial short QT syndrome · score 0.07
Familial progressive cardiac conduction defect · score 0.07
Brugada syndrome 9 · score 0.07
Arrhythmogenic right ventricular dysplasia · score 0.07
familial sick sinus syndrome · score 0.06
long QT syndrome 11 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q58HT5-F1	alphafold	PREDICTED	93.04	—

Amino-acid sequence (328 residues)

MAHSKQPSHF QSLMLLQWPL SYLAIFWILQ PLFVYLLFTS LWPLPVLYFA WLFLDWKTPE RGGRRSAWVR NWCVWTHIRD YFPITILKTK DLSPEHNYLM GVHPHGLLTF GAFCNFCTEA TGFSKTFPGI TPHLATLSWF FKIPFVREYL MAKGVCSVSQ PAINYLLSHG TGNLVGIVVG GVGEALQSVP NTTTLILQKR KGFVRTALQH GAHLVPTFTF GETEVYDQVL FHKDSRMYKF QSCFRRIFGF YCCVFYGQSF CQGSTGLLPY SRPIVTVVGE PLPLPQIEKP SQEMVDKYHA LYMDALHKLF DQHKTHYGCS ETQKLFFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards