About DDB1- and CUL4-associated factor 6
DDB1- and CUL4-associated factor 6 (DCAF6) is a protein
from Homo sapiens identified by UniProt accession
Q58WW2, 860 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | DDB1- and CUL4-associated factor 6 |
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| UniProt accession | Q58WW2 |
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| Gene | DCAF6 |
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| Organism | Homo sapiens |
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| Length | 860 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- Rare genetic intellectual disability with developmental anomaly · score 0.27
- sex hormone-binding globulin measurement · score 0.18
- schizophrenia · score 0.13
- axial length measurement · score 0.06
- neoplasm · score 0.06
- cancer · score 0.03
- testosterone measurement · score 0.03
- protein measurement · score 0.02
- hepatocellular carcinoma · score 0.02
- lumbar disc degeneration · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q58WW2-F1 | alphafold | PREDICTED | 63.37 | — |
Amino-acid sequence (860 residues)
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS GQENENEDEE
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