RUN domain-containing protein 3A (RUNDC3A)

About RUN domain-containing protein 3A

RUN domain-containing protein 3A (RUNDC3A) is a protein from Homo sapiens identified by UniProt accession Q59EK9, 446 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	RUN domain-containing protein 3A
UniProt accession	Q59EK9
Gene	RUNDC3A
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
eosinophil count · score 0.26
monocyte percentage of leukocytes · score 0.18
granulocyte percentage of myeloid white cells · score 0.06
atypical teratoid rhabdoid tumor · score 0.05
glioblastoma multiforme · score 0.04
ependymoma · score 0.03
astrocytoma · score 0.03
lung carcinoma · score 0.03
Ataxia-telangiectasia · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q59EK9-F1	alphafold	PREDICTED	68.17	—

Amino-acid sequence (446 residues)

MEASFVQTTM ALGLSSKKAS SRNVAVERKN LITVCRFSVK TLLEKYTAEP IDDSSEEFVN FAAILEQILS HRFKACAPAG PVSWFSSDGQ RGFWDYIRLA CSKVPNNCVS SIENMENIST ARAKGRAWIR VALMEKRMSE YITTALRDTR TTRRFYDSGA IMLRDEATIL TGMLIGLSAI DFSFCLKGEV LDGKTPVVID YTPYLKFTQS YDYLTDEEER HSAESSTSED NSPEHPYLPL VTDEDSWYSK WHKMEQKFRI VYAQKGYLEE LVRLRESQLK DLEAENRRLQ LQLEEAAAQN QREKRELEGV ILELQEQLTG LIPSDHAPLA QGSKELTTPL VNQWPSLGTL NGAEGASNSK LYRRHSFMST EPLSAEASLS SDSQRLGEGT RDEEPWGPIG KDPTPSMLGL CGSLASIPSC KSLASFKSNE CLVSDSPEGS PALSPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards