Actin maturation protease (ACTMAP)

About Actin maturation protease

Actin maturation protease (ACTMAP) is a protein from Homo sapiens identified by UniProt accession Q5BKX5, 351 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Actin maturation protease
UniProt accession	Q5BKX5
Gene	ACTMAP
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

mucocutaneous lymph node syndrome · score 0.08
myopathy · score 0.06
Congenital myasthenic syndromes · score 0.06
myofibrillar myopathy 3 · score 0.06
tibial muscular dystrophy · score 0.06
inclusion body myopathy with Paget disease of bone and frontotemporal dementia · score 0.05
Distal myotilinopathy · score 0.05
Distal myopathy, Nonaka type · score 0.05
inclusion body myositis · score 0.05
GNE myopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5BKX5-F1	alphafold	PREDICTED	83.19	—

Amino-acid sequence (351 residues)

MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards