Caveolae-associated protein 4 (CAVIN4)

About Caveolae-associated protein 4

Caveolae-associated protein 4 (CAVIN4) is a protein from Homo sapiens identified by UniProt accession Q5BKX8, 364 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Caveolae-associated protein 4
UniProt accession	Q5BKX8
Gene	CAVIN4
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

aspartate aminotransferase measurement · score 0.41
vital capacity · score 0.30
BMI-adjusted waist-hip ratio · score 0.30
grip strength measurement · score 0.27
PHF-tau measurement · score 0.25
adolescent idiopathic scoliosis · score 0.21
creatinine clearance measurement · score 0.17
dilated cardiomyopathy · score 0.12
neoplasm · score 0.08
Thymoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5BKX8-F1	alphafold	PREDICTED	66.04	—

Amino-acid sequence (364 residues)

MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV EDDESLLLDL KHSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards