About Piercer of microtubule wall 1 protein
Piercer of microtubule wall 1 protein (PIERCE1) is a protein
from Homo sapiens identified by UniProt accession
Q5BN46, 136 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Piercer of microtubule wall 1 protein |
|---|
| UniProt accession | Q5BN46 |
|---|
| Gene | PIERCE1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 136 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 36 · score 0.12
- Heterotaxia · score 0.06
- neoplasm · score 0.06
- visceral heterotaxy · score 0.05
- scimitar syndrome · score 0.05
- heterotaxy, visceral, 9, autosomal, with male infertility · score 0.04
- heterotaxy, visceral, 12, autosomal · score 0.04
- right atrial isomerism · score 0.04
- primary ciliary dyskinesia · score 0.04
- renal-hepatic-pancreatic dysplasia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5BN46-F1 | alphafold | PREDICTED | 76.57 | — |
Amino-acid sequence (136 residues)
MAEECPRACA EPVAPKATAP PERTSDYYRV SADLPGRFNN PGWFRGYRTQ KAVSVYRTSN QAYGSRAPTV HEMPKVFYPN SNKFSQQLAA GGMFRNNTLN VYLEKSIVTG PDNCITSCDR LNFHPSYNIN RPSICD
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